Senior Research Associate - Senior Scientist, In-Vivo Editing, CRISPR-X
Company: CRISPR Therapeutics
Location: Boston
Posted on: September 20, 2024
Job Description:
Company OverviewSince its inception over a decade ago,CRISPR
Therapeuticshas transformed from a research-stage company advancing
programs in the field of gene editing, to a company with a diverse
portfolio of product candidates across a broad range of disease
areas including hemoglobinopathies, oncology, regenerative
medicine, cardiovascular and rare diseases. The Nobel Prize-winning
CRISPR science has revolutionized biomedical research and
represents a powerful, clinically validated approach with the
potential to create a new class of potentially transformative
medicines. To accelerate and expand its efforts,CRISPR
Therapeuticshas established strategic partnerships with leading
companies includingBayerand Vertex Pharmaceuticals.CRISPR
Therapeutics AGis headquartered inZug, Switzerland, with its
wholly-ownedU.S.subsidiary,CRISPR Therapeutics, Inc., and R&D
operations based inBoston, MassachusettsandSan Francisco,
California, and business offices inLondon, United Kingdom.Position
SummaryResponsible for in vivo research design and execution across
our next-generation editing modalities team, we are looking for a
motivated and independent researcher/scientist with preclinical &
in vivo gene therapy experience who is excited by the opportunity
to develop innovative gene editing technologies. This individual
will be involved in both hands-on in vivo research and strategic
planning of early-stage discovery and preclinical
project(s).Opportunities in this role include designing our
translational in vivo research strategy to evaluate next-gen
editing technologies, ensuring appropriate resourcing for, and
execution of, all preclinical in vivo studies and reports within
the CRISPR-X research team, authoring preclinical content for
global regulatory submissions, and providing input into
senior-level governance activities and global safety reviews, as
appropriate.Responsibilities
- Lead, design, and execute research with the aims of exploring
and developing next-generation gene editing strategies using
CRISPR-based tools and beyond.
- Responsible for in-vivo research and execution across our
next-generation modalities, covering hepatic and extra-hepatic
target tissues. Lead and conduct hands-on in-vivo research and
strategic planning of preclinical projects.
- Opportunities include designing translational in-vivo research
strategies to evaluate novel editing modalities, ensuring
appropriate resourcing for, and execution of, preclinical in-vivo
editing studies as part of the CRISPR-X team, and authoring
preclinical content for global regulatory submissions.
- Design, execute, and interpret research requiring in-vivo
biology methods including generation, breeding, and maintenance of
genetically engineered mouse models; various injection and animal
surgery techniques; in-vivo assessment of biomarkers and editing
outcomes; longitudinal study of animal health, disease markers, and
phenotypic assays; post-mortem preparation of tissue sections, IHC,
and other assays.
- Analyze and present experimental data to a wide range of
audiences.
- Dissect published literature to find novel solutions to gene
editing problems.
- Generate, manage, evaluate, and maintain critical data in a
highly organized manner, providing statistical analysis and
troubleshooting where appropriate.
- Oversees the construction and maintenance of technical
databases, archives and department procedures manuals required for
the CRISPR-X function.Minimum Qualifications
- Extensive prior experience with general animal procedures,
familiarity with in-vivo gene editing, including applying and
developing next generation gene editing technologies, such as prime
editing, base editing, and recombinases and retrotransposons, in an
academic and/or industry setting, with a track record demonstrating
significant contributions.
- Depending on level, degrees in Biology, Bioengineering, or
related disciplines (level commensurate with experience and
achievement):
- Scientist I - PhD with 0-3 years relevant experience; non-PhD
with 8-10 years progressive, relevant experience
- Scientist II - PhD with 2-5 years relevant experience; non-PhD
with 10-12 years progressive, relevant experience
- Senior Scientist - PhD with 4-8 years relevant experience;
non-PhD with 12-15 years progressive, relevant experience
- Excellent technical skills for rodent (mouse and rat) in vivo
work comprising but not limited to IV injections, blood collection,
necropsy.
- Experience managing multiple programs and priorities, studies,
external CRO management, and budgets.
- Strong communicator and activator personality.
- Highly collaborative team player within and across multiple
departments.
- Ability to manage and teach while still being hands
on.Preferred Qualifications
- Knowledge and experience in advanced in vivo techniques such as
liver perfusion and hepatocyte isolation, and/or measuring lung
function.
- Deep understanding of rodent (mouse and rat) in vivo techniques
ranging from surgical procedures on neonates to physiological and
pathological assessment of diseased adult rodentsCompetencies
- Collaborative - Openness, One Team
- Undaunted - Fearless, Can-do attitude
- Results Orientation - Delivering progress toward our mission.
Sense of urgency in solving problems.
- Entrepreneurial Spirit - Proactive. Ownership mindset.Due to
the nature of their work, our manufacturing and lab-based positions
are located fully on-site.CRISPR Therapeutics, Inc. is committed to
equal employment opportunity and non-discrimination for all
employees and qualified applicants without regard to a person's
race, color, gender, age, religion, national origin, ancestry,
disability, veteran status, genetic information, sexual orientation
or any characteristic protected under applicable law.
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Keywords: CRISPR Therapeutics, Salem , Senior Research Associate - Senior Scientist, In-Vivo Editing, CRISPR-X, Advertising , Boston, Massachusetts
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