Principal Scientist, Early Discovery Biology New Cambridge, MA
Company: Tbwa Chiat/Day Inc
Location: Cambridge
Posted on: October 11, 2024
Job Description:
Principal Scientist, Early Discovery BiologyCambridge, MAWhat
if---you could join an organization that creates, resources, and
builds life sciences companies that invent breakthrough
technologies in order to transform health care and
sustainability?Montai Health is a privately held, early-stage
biotechnology company developing a platform for understanding and
leveraging complex molecular interactions within organisms to solve
global challenges in human health and sustainability. The company
leverages a multidisciplinary approach that integrates tools
ranging from machine learning and big data to multi-omics and
high-throughput screening.At Montai, we nurture a bold, spirited
and leading-edge culture dedicated to strengthening human
health:
- We are one team with omnidirectional trust, empowered and
accountable
- We are strong as individuals but stronger as a team and we are
committed to excellence
- We have a sense of urgency and persistence and we are crazily
confident that we can make a difference
- We need to be comfortable with the uncomfortable and be
rigorous and we recognize that failure is data
- We care for diversity in people, thought, personality,
opinions, background and distinctiveness
- We have a sense of humor to help us manage through our
strategic noiseMontai is seeking an experienced and highly
motivated immunologist at the Principal Scientist level to join the
Early Discovery Biology team, reporting to the head of Early
Discovery Biology. This individual will drive early discovery
programs from project conception and screening/hit ID through
hit-to-lead, leveraging Montai's proprietary AI/ML platform to
deliver clear decision-making data packages. The successful
candidate will have a track record of success leading
interdisciplinary teams to advance small molecule drug discovery
projects in immunology-related therapeutic areas. Primary
responsibilities will include establishing deep understanding of
target biology, developing and executing efficient screening
funnels for HTS & H2L assays via CRO partners, and analyzing and
synthesizing data into decisional packages to ID promising chemical
matter for entry into lead-optimization programs.The ideal
candidate will enjoy working in a collaborative, innovative and
fast-paced biopharmaceutical environment. Skills should include a
high degree of problem-solving ability as well as excellent
communication abilities.Key Responsibilities:
- Provide strategic and technical oversight of development,
validation and execution of in vitro screening and hit-to-lead
programs with external research partners at CROs
- Analyze and compile screening data into Montai databases, and
communicate results to diverse stakeholders to drive project
decisions and progression
- Provide immunology subject matter expertise to support broader
efforts in target & indication prioritization, experimental
approaches and project strategy
- Preparing, reviewing and presenting scientific presentations
for internal/external use
- Work effectively with the leadership team to ensure timely
advancement of projects to meet timelinesQualifications:
- PhD in immunology preferred although biology, pharmacology or a
related scientific discipline would be considered with
drug-discovery experience in inflammatory and immunological
diseases
- 8+ years of industry experience in small molecule drug
discovery-related activities, experience in small start-up is
preferred
- Significant experience independently managing external research
projects with CROs
- Extensive experience with high-throughput screening
methodologies and data analysis
- Strong expertise and research track record in innate and
adaptive immune biology, signaling pathways, and immune functions
in healthy and diseased states including chronic inflammatory and
autoimmune conditions
- Excellent ability to efficiently communicate (written and
verbally) complex and technical content to diverse
stakeholders
- Self-starter who thrives in collaborative interdisciplinary
teams, is unafraid to ask difficult questions, is eager to learn
new biology/technology and is passionate about delivering medicines
to patients suffering with chronic diseasesFlagship Pioneering has
conceived of and created companies such as Moderna Therapeutics
(NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics
(NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo
Agriculture. Since its launch in 2000, Flagship has applied its
unique hypothesis-driven innovation process to originate and foster
more than 100 scientific ventures. In 2021, Flagship Pioneering was
ranked 12th globally on Fortune's "Change the World" list, an
annual ranking of companies that have made a positive social and
environmental impact through activities that are part of their core
business strategies.Flagship Pioneering and our ecosystem companies
are committed to equal employment opportunity regardless of race,
color, ancestry, religion, sex, national origin, sexual
orientation, age, citizenship, marital status, disability, gender
identity or Veteran status.
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Keywords: Tbwa Chiat/Day Inc, Salem , Principal Scientist, Early Discovery Biology New Cambridge, MA, Other , Cambridge, Massachusetts
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